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183 A mitochondria-targeting antioxidant can reduce the production of neutrophil mtROS and result in a decrease in NETosis

The rapid generation of O 2 and H 2 O 2 may mediate a further increase in cytosolic Ca 2+ [41] so elevating glucose metabolism via activation of specific Ca 2+ -sensitive metabolic enzymes (especially those located in the mitochondria), which results in generation of mitochondrial-derived metabolic stimulussecretion coupling factors (such as glutamate, citrate, NADPH and mitochondrially derived ROS) and promotion of insulin secretion (Fig